The objectives of this project are: 1. To develop a center for research in radiation biology, radiation immunology, radiation physics, and related basic sciences and to promote, enhance and stimulate the investigation of the basic mechanisms of radiation and combinations of radiation and other agents in the treatment and control of cancer with the goal of possible human application in mind. 2. To develop and carry out clinical research, utilizing radiation alone or combined with other agents, to improve results in the treatment of human cancer. 3. To provide a center for demonstration and teaching of the appropriate advanced therapeutic methods and techniques so that these can be taught to physicians, medical students, and support personnel of this area and thus be made available to patients. 4. To provide a Training Program in radiation oncology for graduate and undergraduate physicians, technicians and nurses for this region. 5. To develop an Outreach Program to improve radiation therapy treatment in the outlying communities of the region.